Duke won its 550th game in school history on the day.
The 37-point defeat is the worst ever for Old Dominion at home.
In the previous nine meetings with ODU, Duke had not scored more than 83 points and had only broken 80 points one time in 1988. The Blue Devils scored 93 on Sunday.
The Blue Devils blocked 10 shots in the contest and now 17 in two games to start the season.
Sophomore Wanisha Smith registered a career-high 11assists, while scoring three points in 17 minutes. The 11 assists is tied for the fourth-most in school history.
No Duke player played more than 25 minutes in the contest.
For the second straight game, all 11 players who played for Duke scored.
Junior Lindsey Harding scored 16 points in the first half to go along with three assists. She finished with 16 points, three rebounds, three assists and one steal in 23 minutes.
Freshman Abby Waner finished with a game-high 17 points and has scored 32 points in her first two collegiate contests.
Duke hit 52.9 percent of its field goals after hitting 57.4 percent from the field on Friday at Penn State.