Duke held Tennessee to a season-low 53 points for the game and a season-low 23 points in the first half.
Tennessee suffered its worst loss ssince March 29, 2002, when No. 3 Connecticut defeated the Lady Vols, 79-56, in the NCAA final four to end Tennessee's season.
Duke has won 15 straight non-conference home games since the 2004 loss to Tennessee.
The Blue Devils won their second straight contest against Tennessee and evened the series, 4-4.
Duke continued its second-best start in school history with its 19th straight win and is one victory shy of its 10th consecutive 20-win season.
Duke improved to 4-0 against ranked opponents this season.
As a team, Duke shot 53.6 pecent from the field. It marks the 14th time out of 19 games Duke has shot 50.0 percent or better.
Lindsey Harding totaled a career-high eight steals on the night.
Duke's defense forced 22 turnovers, marking the 16th time this season an opponent has had 20 or more turnovers.
Freshman Abby Waner registered eight of her 10 points in the second half off the bench. She hit 2-of-3 three-pointers and 4-of-6 field goals.
Lindsey Harding finished with 15 points, marking the seventh out of the last eight games she has scored double-figure points.
Senior Mistie Williams collected 10 points, nine rebounds and three assists in 30 minutes.
Sophomore Wanisha Smith notched a solid all-around game with seven points, five rebounds and six assists in 21 minutes.
Jessica Foley came off the bench to score eight points, hitting 2-of-4 three-pointers.
Duke held a 30-9 advantage in points off the bench. Twenty-one of those points for Duke came in the second half.
The Blue Devils played in front of their fifth-ever sellout of 9,314 in school history.
Duke will next travel to Clemson, S.C. for a 7:00 p.m. contest against the Lady Tigers on Thursday, Jan. 26.