Duke won its 18th straight home contest against non-conference opponents.
For the third straight game, sophomore Abby Waner scored double-figures as she posted a first half best 11 points, four rebounds, three assists and two steals in 16 first half minutes. She finished the game with 15 points, six rebounds, six assists and three steals in 25 minutes.
Abby Waner's eight three-point field goal attempts tied a career high.
Freshman Bridgette Mitchell finished the contest with 16 points and 12 rebounds, marking the second double-double in three games this season.
Senior Alison Bales blocked five shots on the day and now needs one block to move into a tie for third on the ACC career blocked shots list tying Peggy Caple of Clemson (298). Bales has 297 for her career and 14 so far in three games.
Alison Bales also scored a season-high 16 points and had six rebounds in 22 minutes against Houston.
Duke held a 48-16 points in the paint advantage on the day.
Senior Lindsey Harding dished out a season-high six assists to go along with eight points and five rebounds in 21 minutes.
Duke continued to struggle shooting, hitting only 44.6 percent from the field and 23.5 percent from three-point land.
Junior Emily Waner dished out three assists and had four rebounds, which both tied a career high.
A total of five Duke players had at least one block on the day and as a team the Blue Devils blocked nine shots.
Sophomore Carrem Gay pulled down eight rebounds marking the third straight contest she has totaled six or more rebounds.
Duke had 29 points off turnovers, while Houston had three.
The Blue Devils out-rebounded its opponent for the third straight game as Duke held a 58-36 advantage against the Cougars.
All 10 Duke players who played scored at least two points on the day.
Duke will next host Penn State on Tuesday, Nov. 21 at 7:00 PM, which will conclude a four-game home stand.