Duke won its 31st straight game in the month on December.
The Blue Devils improved to 10-0 to start the season for the third time under Head Coach Gail Goestenkors and the fourth time overall in Duke history.
Duke played its first game in nine days as the Blue Devils had a break for exams.
For the seventh time this season, Duke held its opponents to under 30.0 percent shooting as Bowling Green was limited to 29.1 percent from the field.
Duke finished off a four-game stretch against ranked opponents with four victories. The Blue Devils are 54-18 against ranked opponents over the last six years.
Going into the game, Bowling Green' sLiz Honegger was second in the nation in three-point field goal percentage but Duke held her to 0-for-10.
Duke tied a season high with 23 turnovers on the night.
The Blue Devils outrebounded their opponent (36-33) for the 10th straight game.
Wanisha Smith scored double-figures for the third straight game as she scored nine of her 11 points in the second half.
Senior Alison Bales became the ACC's all-time blocked shots leader with her five rejections in the first half. Bales went on to finish with seven for the game. She now owns 335 for her career passing Virginia's DeMya Walker (330). Bales also moved into 20th place on the NCAA's all-time blocks list.
Duke's 25 points in the first half was a season low and the 55 points was as season low.
Senior Lindsey Harding moved into fourth place on the Duke all-time steals list (229) with her three swipes on the evening.
Sophomore Abby Waner had her nine-game double-figure scoring streak stopped as she finished with nine points.
Alison Bales scored double-figures for the sixth straight game as she totaled 13 points to go along with eight rebounds, seven blocks and two steals.
Duke will next take on SMU in the Caribbean Classic on Wednesday at 4:30 p.m. EST.