Duke won its 74th straight game against an unranked opponent.
Chante Black registered her seventh career double-double with 16 points and 11 rebounds in 21 minutes.
All 12 Blue Devils played for the second straight contest to open the season. For the first time this season, all 12 Duke players also scored.
Redshirt sophomores Keturah Jackson and Brittany Mitch each made their first career starts on the night for the Blue Devils. The last time two players started their first career games in the same contest was on Nov. 12, 2004 versus Davidson. Jessica Foley, Chante Black and Caitlin Howe each started in the season opener.
Brittany Mitch left the game early in the second half to receive five stitches under her right eye.
In the second half at Denver and the first half versus South Florida, Duke's defense held its opponents to only eight baskets over the 40 minutes.
Joy Cheek collected a career-high 15 points on the night marking the second straight game she has scored double-figures (had 11 at Denver).
After playing one minute in the first half with two fouls, freshman Krystal Thomas scored 10 points, had six blocks, three rebounds and one assist in 14 minutes in the second half.
Sophomore Bridgette Mitchell came off the bench and pulled down eight rebounds.
For the second consecutive game, Duke outrebounded its opponent, 55-42.
In two games this season, the Blue Devil defense has held their opponent to under 30.0 percent shooting. South Florida was limited to 27.7 percent.
Keturah Jackson pulled down a career-high seven rebounds in her first career start. \
Duke has won 16 straight games in the month of November.
Senior Wanisha Smith scored nine points and is now 13 away from reaching the 1,000 career point mark.
Junior Abby Waner missed the game due to a high ankle sprain suffered on Tuesday evening at practice. She broke a streak of 70 consecutive games played.
Duke dished out a total of 25 assists on the evening.
Duke will next return to Durham, N.C. for the 2007-08 home opener on Sunday, Nov. 18 at 2:00 p.m. against UNC Greensboro.