Duke's 44.1 field goal percentage in the first half was the second-best this season, but the Blue Devils shot 30.4 percent in the second half and finished the game with a 38.6 percentage.
Freshman Jasmine Thomas registered 12 points on the evening marking the third time out of the last four games she has notched double-figure points.
After getting outrebounded in the last two games, Duke came out and posted a 19-11 advantage in the first half. The Blue Devils finished the contest with a 39-29 rebounding advantage.
Junior Chante Black registered her sixth straight game with double-figure points as she finished with 10 for the game. She also posted her third double-double of the season with 10 rebounds as well. Black's double-double was the ninth of her career.
Duke concluded the game with 24 turnovers which is the second-most of the season in a single game.
The Blue Devils lost back-to-back games for the first time since 1999-2000.
The win by Vanderbilt moves it back to 3-2 in the overall series.
Duke allowed Vanderbilt to go to the foul line 30 times and hit 22 of the attempts.
The Blue Devils had a season-low eight assists.
Duke attempted a season-low 11 free throws.
In her second game back from an ankle injury, Abby Waner scored nine points in 25 minutes.
Freshman Krystal Thomas suffered a kneecap injury in the first half and did not return to action.
Senior Wanisha Smith missed the contest due to her injured hand in which she injured in the South Florida contest on Nov. 15.
The Blue Devils are in the middle of a five-game road trip...here are a couple of notes about the trip:
Duke has only one home game over the first eight contests, which is a new school record -- closest was two over the first eight games in 1979-80.
Duke will continue its five-game road trip on Sunday, Dec. 2 with a contest at Penn State. The match will be aired live on ESPN2 in a part of the ACC/Big Ten Challenge.