Duke's 24-game home winning streak came to an end, which was the longest current streak in the nation.
The Blue Devils had their 27-game winning streak against non-conference opponents broken.
The Blue Devils record in sellout crowds at Cameron Indoor Stadium drops to 5-4.
Tennessee evens the series, 5-5, breaking a three-game winning streak for Duke.
Abby Waner moved into fourth place on Duke's all-time three-point field goals attempted list with 418.
Freshman Jasmine Thomas tied a career high with three treys on the night on four attempts. She also posted double-figure scoring for the eighth time this season with 13 points. She also had three steals, one assist and one rebound in 30 minutes.
The Blue Devils were outrebounded 40-29 to the Lady Vols. Duke had outrebounded its opponents in seven out of the last eight games and had a rebound margin of 15.3 in those contests.
Tennessee registered 11 offensive rebounds in the first half and a 13-0 second chance points advantage. The Lady Vols finished the game with a 21-0 second chance points advantage.
Senior Wanisha Smith registered double-figure scoring for the sixth time this season and the third straight contest as she finished the contest with 12 points. She also had four rebounds, three assists and two steals.
In Duke's five losses this season, the Blue Devils' opponents have hit 120-of-149 free throws, while Duke has hit 36-of-62. On the night, Tennessee was 17-of-22 from the line and Duke was 7-of-12
Abby Waner's three-pointer with 47 seconds remaining to tie the game broke a streak of 16 straight misses at home in Cameron Indoor Stadium. Waner finished the game with eight points, six assists, four rebounds and one block.
Sophomore Joy Cheek registered a season-high four steals on the night to go along with a team-high eight rebounds and six points.
Duke falls to 3-4 against ranked opponents on the season.
Junior Chante Black collected 13 points to go along with two rebounds, one assist and one steal in 30 minutes. She totaled double-figure scoring for the 17th time out of 20 games. The two rebounds was a season-low for Black.
The Blue Devils shot 50.0 percent from the field in the first half, equalling the second-best percentage in the first half this season.
Duke was tied, 33-33, at the half marking the second time this season the Blue Devils were tied at intermission (Pittsburgh).
In the first half, all eight players who played for Duke scored at least one basket.
The Blue Devils forced 23 Tennessee turnovers marking the 13th time this season Duke has made its opponent turn the ball over 20 or more times.
Duke moved to No. 9 in the Associated Press poll, which was released on Monday.
Sophomore Keturah Jackson came off the bench with a strong effort scoring six points, grabbing three rebounds, one assist and one steal in a season-high 26 minutes.
The Blue Devils had their ninth sellout crowd of 9,314 in school history on the night.
Duke had all 12 players available for only the sixth game this season.
Duke will next host Virginia Tech on Friday, Feb. 1 at 7:00 p.m., in Cameron Indoor Stadium.