Duke improved to 13-0 in home openers under Head Coach Gail Goestenkors.
The Blue Devils reached the 100-point mark in a season-opener for only the sixth time in school history.
A total of five Blue Devils had double-figure scoring on the day.
Joy Cheek finished with 12 points and 11 rebounds for a double-double, while Bridgette Mitchell also had a double-double with 18 points and 13 rebounds. They became the first Duke freshmen to notch a double-double in their first collegiate game since Monique Currie posted 17 points and 10 rebounds against Texas Tech on Nov. 11, 2001.
It marked the first time in school history two freshmen have had double-doubles in the season-opener for the Blue Devils.
Bridgette Mitchell's 13 rebounds ranks tied for eighth in the Duke freshman single game charts.
Sophomore Carrem Gay made her first career start in Saturday's contest and tied a career high with 14 points in the first half as she hit 4-of-6 field goals and 6-of-8 free throws.She finished with a career-best 16 points, six rebounds, while hitting 5-of-7 field goals in 21 minutes.
As a team, Duke blocked 11 shots on the afternoon led by Alison Bales with (5).Seven different Blue Devils had a block on the day.
Sophomore Abby Waner finished with 16 points to go along with five steals, four rebounds and one assist in 22 minutes.
Duke forced 36 Huskie turnovers on the afternoon and had 40 points off turnovers.
In only her fourth collegiate game, redshirt freshman Brittany Mitch came off the bench to score 10 second half points, while also grabbing three steals and two assists in 19 minutes.
Abby Waner (5), Lindsey Harding (5) and Wanisha Smith (4) combined to post 14 steals.As a team, Duke had 24 steals which was one shy from a school record.
Senior Alison Bales had 11 rebounds, eight points and five blocks in her season opener.
Duke posted a 63-29 rebound margin and was five rebounds shy of a school record.
No Blue Devil played more than 23 minutes on the afternoon.
As a team, Duke shot 51.2 percent from the field in the second half and 44.4 percent for the game.
Duke will next host Marist Friday, Nov. 17 at 7:00 PM, which will be the second of four straight home contests for the Blue Devils.