Senior Lindsey Harding was named MVP of the tournament, while Abby Waner was selected to the All-Tournament team.
Duke allowed a season-low eight points and 10.5 percent shooting in the first half and a season-high 41.4 percent in the second half.
The Blue Devils continue on their third-best start in school history with a 14-0 record.
Duke won its 34th consecutive game in the month of December.
Duke won its 61st straight game against an unranked opponent and 32nd straight game against non-conference foes.
Duke hit its first three free throws on the night but missed the fourth ending a streak of 33 straight free throws made by the Blue Devils.
Sophomore Carrem Gay posted a career-high 22 points to go along with 10 rebounds on the night. The double-double was her second of the season and her career. All this was done in only 22 minutes.
Senior Lindsey Harding notched double-figure points for the third straight game and seventh out of the last eight contests as she finished with 17. She also dished out two assists, had two rebounds and two steals.
Alison Bales notched 12 points, marking the ninth time out of the last 10 games she has recorded double-figure points. She also pulled down six rebounds, two assists and four blocks.
The Blue Devils held Boston University to 29.2 percent shooting marking the 10th time this season out of 14 games Duke has held its opponent to under 30.0 percent shooting.
Emily Waner hit a three-pointer for the ninth straight game as she hit 1-of-3 from downtown. She finished with three points on the night.
Duke outrebounded its opponent for the 13th time this season, 42-26.
The Blue Devils shot 61.5 percent from the field in the second half.
Duke remains one of only five undefeated teams in NCAA Division I.
Duke will next host Miami on Jan. 3 at 7:00 p.m., which will mark the ACC opener for both teams.]